ALEXIS Biochemicals: Polyclonal Antibody to Asc (AL177)

ALX-210-905

Revised 23-May-08

Polyclonal Antibody to Asc (AL177)
SYNONYMS	anti-Pycard PAb (AL177) anti-Apoptosis-associated Speck-like Protein Containing CARD PAb (AL177) anti-TMS1 PAb (AL177) anti-Target of Methylation-induced Silencing 1 PAb (AL177) anti-CARD5 PAb (AL177) anti-Caspase Recruitment Domain-containing Protein 5 PAb (AL177)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Inflammasome

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-905-R100		100 µl	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Epitope-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 2-27 (G²RARDAILDALENLTAEELKKFKLKL²⁷) of N-terminal human Asc (apoptosis-associated speck-like protein containing CARD; Pycard).
SPECIFICITY:	Recognizes human and mouse Asc.
APPLICATION:	Immunocytochemistry Immunoprecipitation Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.
POSITIVE CONTROL:	For Positive Control (Western blot) see Prod. No. ALX-840-602.

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Product Specific Literature References

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon, et al.; Mol. Cell. 10, 417 (2002) Abstract
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini, et al.; Immunity 20, 319 (2004) Abstract
P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1{beta} in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Signalling: Initiation of pro-IL-1beta processing: E. Bell; Nat. Rev. Immunol. 2, 719 (2002) Abstract
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1: S.M. Srinivasula, et al.; J. Biol. Chem. 277, 21119 (2002) Abstract
NALPS: a novel protein family involved in inflammation: J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol. 4, 95 (2003), (Review) Abstract; Full Text

Further Categories Containing This Product:

Caspase Recruitment Domain [CARD] Proteins / Related Products • Polyclonal Antibodies

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