ALEXIS Biochemicals: Polyclonal Antibody to ANGPTL4 (rat)

ALX-210-360

Revised 29-Sep-05

Polyclonal Antibody to ANGPTL4 (rat)
SYNONYMS	anti-Angiopoietin-like Protein 4 (rat) PAb anti-FIAF (rat) PAb anti-Fasting-induced Adipose Factor (rat) PAb anti-HFARP (rat) PAb anti-Hepatic Fibrinogen/Angiopoietin-related Protein (rat) PAb
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Angiopoietin-like Proteins [ANGPTLs]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-360-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Rat
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Epitope-affinity purified.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 80-94 (C⁸⁰QGPKGKDAPFKDSE⁹⁴) of mouse ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:	Recognizes rat ANGPTL4. Detects a band of ~50kDa by Western blot.
APPLICATION:	Western Blot (2µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-156-004.

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Product Specific Literature References

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene: S. Kersten, et al.; J. Biol. Chem. 275, 28488 (2000) Abstract; Full Text

General Information

Adipose tissue is an energy reserve in animals and, in nondomestic species, is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as leptin and adiponectin. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor α (PPARα). PPARα has been reported to target a gene encoding the secreted protein ANGPTL4 (angiopoietin-like protein 4; FIAF; fasting-induced adipose factor). ANGPTL4 is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that ANGPTL4 represents an endocrine signal helping to regulate metabolism, especially under fasting conditions.