ALEXIS Biochemicals: Polyclonal Antibody to BAG-1 (Bur 1680)

ALX-210-011

Revised 22-Apr-08

Polyclonal Antibody to BAG-1 (Bur 1680)
SYNONYMS	anti-Bcl-2 Associated Athanogene-1 PAb (Bur 1680) anti-BAG Family Molecular Chaperone Regulator 1 (Bur 1680) PAb
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Bcl-2 Family Interacting Proteins/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-011-R050		50 µl	190.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse Rat
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:	Recombinant mouse BAG-1 (Bcl-2 associated athanogene-1) (aa 8-219).
SPECIFICITY:	Recognizes mouse and rat BAG-1.
APPLICATION:	Immunocytochemistry (1:100) Immunohistochemistry (paraffin sections (1:5'000)) Western Blot (1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Bag1 is a regulator and marker of neuronal differentiation: P. Kermer, et al.; Cell Death Differ. 9, 405 (2002) Abstract

General Information

BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions: S. Alberti, et al.; Cell Stress Chaperones 8, 225 (2003) Abstract; Full Text
BAG-1: a multi-functional pro-survival molecule: P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol. 37, 251 (2005) Abstract

Further Categories Containing This Product:

Co-Chaperones & HSP-interacting Proteins/Related Products • Chaperone-mediated Autophagy [CMA] • Polyclonal Antibodies • Ubiquitin Ligases [E3]

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