ALEXIS Biochemicals: Polyclonal Antibody to ARAP1 (human)

ALX-210-571

Revised 10-Apr-08

Polyclonal Antibody to ARAP1 (human)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	GTPase-activating Proteins [GAPs]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-571-C100		100 µg	380.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY:	Liquid. In PBS.
IMMUNOGEN:	Recombinant C-terminal part of mouse ARAP1 (aa 1084-1371).
SPECIFICITY:	Recognizes human ARAP1.
APPLICATION:	Western Blot (1µg/ml) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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General Information

The adaptor protein ARAP1 is a PIP3-dependent Arf GAP that regulates Arf-, Rho-, and Cdc42-dependent cell activities. ARAP1 plays an important role in the regulation of blood pressure and renal function via activation of the intrarenal renin-angiotensin system. It was shown that ARAP1 might affect the efficacy of TRAIL-induced apoptosis due to its cell-specific trafficking of TRAIL-R1 (DR4).

General Literature References

ARAP1: a point of convergence for Arf and Rho signaling: K. Miura, et al.; Mol. Cell 9, 109 (2002) Abstract
Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney: D.F. Guo, et al.; Hypertension 48, 453 (2006) Abstract; Full Text
Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane: S. Simova, et al.; Apoptosis 13, 423 (2008) Abstract

Further Categories Containing This Product:

Renin-Angiotensin-Aldosterone System [RAAS] Other Products • Polyclonal Antibodies

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