ALEXIS Biochemicals: Polyclonal Antibody to Ah Receptor Nuclear Translocator 3

ALX-210-245

Revised 21-Nov-06

Polyclonal Antibody to Ah Receptor Nuclear Translocator 3
SYNONYMS	anti-ARNT3 PAb anti-BMAL1 PAb anti-Brain & Muscle ARNT-like 1 PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Aryl Hydrocarbon Receptor / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-245-R200		200 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 582-594 (CD⁵⁸²MIDNDQG SSSPS⁵⁹⁴) of mouse ARNT3 (Ah receptor nuclear translocator 3).
SPECIFICITY:	Recognizes human and hamster ARNT3.
APPLICATION:	Western Blot (1:200)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-152-023.

General Information

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK-BMAL1 has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian the timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.

Further Categories Containing This Product:

Circadian Transcriptional Regulators / Related Products • Polyclonal Antibodies

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