ALEXIS Biochemicals: Polyclonal Antibody to CD51

ALX-210-537

Revised 10-Apr-08

Polyclonal Antibody to CD51
SYNONYMS	anti-αV Integrin PAb Polyclonal Antibody to Vitronectin Receptor (α Subunit) anti-Vitronectin Receptor (α Subunit) PAb
PRODUCT LINE	Immunology
PRODUCT CATEGORY	CD Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-537-R100		100 µl	220.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Goat Sheep Dog Pig Monkey
SOURCE/HOST:	From rabbit.
PURITY:	Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain).
SPECIFICITY:	Recognizes cytoplasmic domain of CD51 of all species.
APPLICATION:	ELISA Immunocytochemistry (1:1’000) Immunohistochemistry (1:1’000) Immunoprecipitation (5µl per 5x10⁶ cells) Western Blot (1:5’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development: E. Hirsch, et al.; Dev. Dyn. 201, 108 (1994) Abstract

General Information

CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.

Further Categories Containing This Product:

Angiogenesis Other Products • Polyclonal Antibodies • Bone Metabolism Other Products • Adhesion Molecules & Receptors Antibodies

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