ALEXIS Biochemicals: Polyclonal Antibody to DPR1

ALX-215-059

Revised 25-Jun-08

Polyclonal Antibody to DPR1
SYNONYMS	anti-Dapper Homolog 1 PAb anti-HNG3 PAb anti-Hepatocellular Carcinoma Novel Gene 3 Protein PAb anti-Thymus-expressed Novel Gene 3 Protein PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Wnt Signalling Pathway Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-215-059-C100		100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
CONCENTRATION:	0.75mg/ml
PURITY DETAIL:	Protein A-affinity purified.
FORMULATION:	Liquid. In PBS
IMMUNOGEN:	Recombinant human DPR1 (Dapper homolog 1) (aa 282-516).
SPECIFICITY:	Recognizes human and mouse DPR1. Detects a band of ~90kDa.
APPLICATION:	Immunocytochemistry (1:100-1:200) Immunoprecipitation (1:100-1:200) Western Blot (1:1’000-1:5’000) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least one year after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Product Specific Literature References

Dapper 1 Antagonizes Wnt Signaling by Promoting Dishevelled Degradation: L. Zhang, et al.; J. Biol. Chem. 281, 8607 (2006) Abstract; Full Text

General Information

Members of the Dact protein family initially were identified through binding to Dishevelled (Dvl), a cytoplasmic protein central to Wnt signalling. DPR1 inhibits Wnt signalling. During mouse development, DPR1 is detected in the presomitic mesoderm and somites during segmentation, in the limb bud mesenchyme and other mesoderm-derived tissues, and in the central nervous system (CNS). Dact paralogs have distinct signalling and developmental roles and suggest they may differentially contribute to postnatal brain physiology.

General Literature References

HDPR1, a novel inhibitor of the WNT/β-catenin signaling, is frequently
downregulated in hepatocellular carcinoma: involvement of methylationmediated
gene silencing: TO. Yau, et al.; Oncogene 24, 1607 (2005) Abstract
Dapper, a Dishevelled-Associated Antagonist of β-Catenin and JNK Signaling, Is Required for Notochord Formation: B. Cheyette, et al.; Developmental Cell 2, 449 (2002) Abstract

Further Categories Containing This Product:

Polyclonal Antibodies

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