ALEXIS Biochemicals: Polyclonal Antibody to Glucocorticoid Receptor

ALX-210-131

Revised 19-Nov-07

Polyclonal Antibody to Glucocorticoid Receptor
SYNONYMS	anti-GR PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Glucocorticoids & Glucocorticoid Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-131-C050		50 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
SOURCE/HOST:	From rabbit.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Lyophilized.
RECONSTITUTION:	Reconstitute with PBS.
IMMUNOGEN:	Synthetic peptide corresponding to aa 346-367 (D³⁴⁶QKPIFNVIPPIPVGSENWNRC³⁶⁷) of human GR (glucocorticoid receptor).
SPECIFICITY:	Recognizes all forms of human, mouse and rat GR. Detects a band of ~97kDa by Western blot. Does not interfere with receptor DNA binding.
APPLICATION:	Immunocytochemistry (1µg/ml) Immunohistochemistry (paraffin sections) Western Blot (5µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-157-015.

Product Specific Literature References

Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors: J.A. Cidlowski, et al.; Mol. Endocrinol. 4, 1427 (1990) Abstract
Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells: J.E. Pawlowski, et al.; J. Biol. Chem. 277, 20702 (2002) Abstract; Full Text
Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells: E.R. James, et al.; Invest. Ophthalmol. Vis. Sci. 44, 5269 (2003) Abstract; Full Text
Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A: D.L. Drazen, et al.; Endocrinology 145, 3404 (2004) Abstract