ALEXIS Biochemicals: Polyclonal Antibody to Glucocorticoid Receptor Interacting Protein 1

ALX-210-286

Revised 15-Jun-06

Polyclonal Antibody to Glucocorticoid Receptor Interacting Protein 1
SYNONYMS	anti-GRIP1 PAb anti-TIF2 PAb anti-Transcriptional Intermediatory Factor 2 PAb anti-SRC-2 PAb anti-Steroid Receptor Coactivator-2 PAb anti-NCOA2 PAb anti-Nuclear Receptor Coactivator 2 PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Glucocorticoids & Glucocorticoid Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-286-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 206-217 (P²⁰⁶LPDSEEEGHDS²¹⁷C) of human GRIP1 (glucocorticoid receptor interacting protein-1).
SPECIFICITY:	Recognizes human and hamster GRIP1.
APPLICATION:	Immunocytochemistry (1:1’000) Immunohistochemistry (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-157-019.

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Product Description

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. GRIP1 (Glucocorticoid Receptor Interacting Protein-1), or TIF2 (Transcription Intermediary Factor 2), is a member of a growing family of transcriptional coactivator proteins which includes SRC-1 and AIB1. GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.

Further Categories Containing This Product:

Nuclear Receptor Coactivators / Related Products • Polyclonal Antibodies

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