ALEXIS Biochemicals: Polyclonal Antibody to HERG1B

ALX-215-051

Revised 24-Jun-08

Polyclonal Antibody to HERG1B
SYNONYMS	anti-Erg1B PAb anti-Ether-a-go-go Related Protein 1B PAb anti-KCNH2 (Isoform B) PAb anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform B) PAb anti-Voltage-gated Potassium Channel Kv11.1 (Isoform B) PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	K+ Channel Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-215-051-R100		100 µl	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
PURITY DETAIL:	Affinity purified.
FORMULATION:	Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN:	Synthetic peptide corresponding to aa 15-28 (R¹⁵PRAQKGRVRRAVR²⁸) of HERG1B (human ether-a-go-go related protein 1B).
SPECIFICITY:	Recognizes HERG1B and mouse Erg1B isoform.
APPLICATION:	Immunocytochemistry (1:50-1:200) Immunohistochemistry (frozen sections) (1:100) Western Blot (1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	-20°C
LONG TERM STORAGE:	-80°C
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.

Product Specific Literature References

Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K⁺ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. Epub ahead of print, (2008) Abstract

General Information

The ether-a-go-go related gene family of K⁺ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Further Categories Containing This Product:

Cancer Other Products • Polyclonal Antibodies

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