ALEXIS Biochemicals: Polyclonal Antibody to HERG1 (CT) (pan)

ALX-215-049

Revised 21-Aug-08

Polyclonal Antibody to HERG1 (CT) (pan)
SYNONYMS	anti-Erg1 (CT) (pan) PAb anti-Ether-a-go-go Related Protein 1 (CT) (pan) PAb anti-KCNH2 (CT) (pan) PAb anti-Voltage-gated Potassium Channel Subfamily H Member 2 (CT) (pan) PAb anti-Voltage-gated Potassium Channel Kv11.1 (CT) (pan) PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	K+ Channel Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-215-049-R100		100 µl	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Neat serum.
IMMUNOGEN:	Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1106-1158).
SPECIFICITY:	Recognizes C-terminal epitope of HERG1 and mouse Erg1. Recognizes both isoforms HERG1A and HERG1B.
APPLICATION:	Flow Cytometry (1:1'000) Immunocytochemistry (1:100-1:200) Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400) Western Blot (1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells: E. Lastraioli, et al.; Cancer Res. 64, 606 (2004) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines: A. Masi, et al.; Br. J. Cancer 93, 781 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K⁺ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008) Abstract

General Information

The ether-a-go-go related gene family of K⁺ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Further Categories Containing This Product:

Cancer Other Products • Polyclonal Antibodies

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