ALEXIS Biochemicals: Polyclonal Antibody to Histone Deacetylase 2

ALX-210-257

Revised 15-May-06

Polyclonal Antibody to Histone Deacetylase 2
SYNONYMS	anti-HDAC2 PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	HDAC Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-257-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Dog Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 475-488 (CT⁴⁷⁵DTKGTKS EQLSNP⁴⁸⁸) of human HDAC2 (histone deacetylase 2).
SPECIFICITY:	Recognizes human, mouse, rat, hamster and dog HDAC2. Detects a band of ~55kDa by Western blot. Also detects a band of ~40KDa of unknown identity.
APPLICATION:	Flow Cytometry Immunocytochemistry (1µg/ml) Immunohistochemistry (0.4µg/ml) Immunoprecipitation Western Blot (0.5µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-158-007.

Product Specific Literature References

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription: Y. Ling, et al.; Nucl. Acids Res. 32, 598 (2004) Abstract; Full Text

General Literature References

Roles of histone acetyltransferases and deacetylases in gene regulation : M.H. Kuo & C.D. Allis; Bioessays 20, 615 (1998), (Review) Abstract
Cloning and characterization of the mouse histone deacetylase-2 gene: Y. Zeng, et al.; J. Biol. Chem. 273, 28921 (1998) Abstract; Full Text
Ligand-induced recruitment of a histone deacetylase in the negative- feedback regulation of the thyrotropin beta gene : S. Sasaki, et al.; EMBO J. 18, 5389 (1999) Abstract; Full Text