ALEXIS Biochemicals: Polyclonal Antibody to LRRK2 (human) (AT106)

ALX-210-928

Revised 08-Nov-07

Polyclonal Antibody to LRRK2 (human) (AT106)
SYNONYMS	anti-Leucine-rich Repeat Kinase 2 (human) PAb (AT106) anti-RIP7 (human) PAb (AT106) anti-PARK8 (human) PAb (AT106) anti-Dardarin (human) PAb (AT106)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	RIP Kinases

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-928-C100		100 µg	350.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Epitope-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human LRRK2 (leucine-rich repeat kinase 2) (aa 1838-2133).
SPECIFICITY:	Recognizes human LRRK2. The strongest recognized epitope is PDQPRLTIPISQ (aa 1843-1854) as defined by epitope mapping.
APPLICATION:	Immunohistochemistry (paraffin sections (1:500)) Immunoprecipitation (1:100) Western Blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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Product Specific Literature References

LRRK2 in Parkinson’s disease and dementia with Lewy bodies: X. Zhu, et al.; Mol. Neurodegener. 1, 17 (2006) Abstract; Full Text

General Information

LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease: C. Paisan-Ruiz, et al.; Neuron 44, 595 (2004) Abstract
From The Cover: Parkinson’s disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity: A.B. West, et al.; PNAS 102, 16842 (2005) Abstract
The RIP kinases: crucial integrators of cellular stress: E. Meylan and J. Tschopp; TIBS 30, 151 (2005) Abstract

Further Categories Containing This Product:

Polyclonal Antibodies • Parkinson's Disease Other Products

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