ALEXIS Biochemicals: Polyclonal Antibody to Leptin

ALX-210-166

Revised 13-Dec-04

Polyclonal Antibody to Leptin
SYNONYMS	anti-OB Gene Product PAb
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Leptin / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-166-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Pig
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Purified IgG in PBS containing 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 91-106 (S⁹¹RNVIQIS NDLENLRD¹⁰⁶) of human leptin.
SPECIFICITY:	Recognizes human, mouse and pig leptin. Detects a band of ~16kDa by Western blot.
APPLICATION:	Western Blot (1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

Leptin, the obese (ob) gene product, is a small protein expressed in and secreted from adipose tissue of normal rodents. Studies suggest leptin acts as a circulating hormone capable of regulating body-weight homeostasis and energy balance. One possible target tissue for leptin is the hypothalamus, a proposed control center for satiety and energy expenditure.
Ob knockout mice are characterized by several metabolic abnormalities including, hyperglucocorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered central nervous system activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue. Studies show that the administration of recombinant leptin to ob knockout mice reduces food intake and increases energy expenditure.

Further Categories Containing This Product:

Polyclonal Antibodies

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