ALEXIS Biochemicals: Polyclonal Antibody to MDA5 (mouse) (AL180)

ALX-210-352

Revised 30-Oct-06

Polyclonal Antibody to MDA5 (mouse) (AL180)
SYNONYMS	anti-Melanoma Differentiation-associated Gene 5 (mouse) PAb (AL180) anti-Helicard (mouse) PAb (AL180)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	RNA Helicases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-352-C100		100 µg	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Contains 0.02% sodium azide.
IMMUNOGEN:	Recombinant mouse MDA5 (melanoma differentiation-associated gene 5) (aa 2-208).
SPECIFICITY:	Recognizes mouse MDA5.
APPLICATION:	Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation: M. Kovacsovics, et al.; Curr. Biol. 12, 838 (2002) Abstract

General Information

MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002) Abstract

Related Products

ALX-210-935	Polyclonal Antibody to MDA5 (human) (AT113)
ALX-804-863	Monoclonal Antibody to MDA5 (human) (Hely-1)
APO-54N-035	MDA5 (human) Detection Set (IntraCellular) [For ELISA Application]
APO-54N-039	MDA5 (human) ELISA Kit (IntraCellular)

Further Categories Containing This Product:

NF-kB Pathway Other Products • Antiviral Signalling / Related Products • Polyclonal Antibodies • Caspase Recruitment Domain [CARD] Proteins / Related Products • Interferons & Interferon Receptors Other Products

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