ALEXIS Biochemicals: Polyclonal Antibody to Osteoblast Specific Factor 2

ALX-210-399

Revised 29-Jan-08

Polyclonal Antibody to Osteoblast Specific Factor 2
SYNONYMS	anti-OSF-2 PAb anti-Periostin PAb anti-Fasciclin-I-like PAb
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	Heparin Binding Factors/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-399-C050		50 µg	430.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Rat Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	0.5mg/ml after reconstitution.
PURITY DETAIL:	Protein G-affinity purified and sterile filtered.
FORMULATION:	Lyophilized from 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION:	Reconstitute with 100µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN:	Recombinant human OSF-2 (osteoblast specific factor 2).
SPECIFICITY:	Recognizes human, rat and chicken OSF-2.
APPLICATION:	ELISA Immunocytochemistry Immunohistochemistry (paraffin sections (1:100-1:5'000)) Western Blot (0.1-1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.

Product Specific Literature References

Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre: M.J. Blumer, et al.; J. Anat. 208, 695 (2006) Abstract
A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer: V. Castronovo, et al.; Mol. Cell. Proteomics 5, 2083 (2006) Abstract; Full Text
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data: A. Grigoriadis, et al.; Breast Cancer Res. 8, R56 (2006) Abstract; Full Text
Immunohistochemical localization of alpha-Smooth muscle actin during rat molar tooth development: A. Hosoya, et al.; J. Histochem. Cytochem. 54, 1371 (2006) Abstract
Quantification of membrane and membrane-bound proteins in normal and malignant breast cancer cells isolated from the same patient with primary breast carcinoma: X. Liang, et al.; J. Proteome Res. 5, 2632 (2006) Abstract
ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells: P. Li, et al.; J. Appl. Physiol. 102, 390 (2007) Abstract
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity: M. Erkan, et al.; Gastroenterology 132, 1447 (2007) Abstract

General Information

OSF-2 functions as a cell-adhesion molecule for pro-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Patients with bone metastases from breast (but not lung) cancer show elevated levels of OSF-2. OSF-2 expression is significantly increased by bone morphogenetic protein 2 (BMP-2).

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Polyclonal Antibodies

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