ALEXIS Biochemicals: Polyclonal Antibody to PAF Acetylhydrolase (human)

ALX-210-765

Revised 24-Jan-05

Polyclonal Antibody to PAF Acetylhydrolase (human)
SYNONYMS	anti-Platelet Activating Factor Acetylhydrolase (human) PAb
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Platelet Activating Factors [PAF] & Receptors/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-765-1		1 Vial	269.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
QUANTITY:	Sufficient for ten (10x10cm) immunoblots.
FORMULATION:	Lyophilized.
RECONSTITUTION:	Reconstitute with 100µl distilled water.
IMMUNOGEN:	Synthetic peptide corresponding to aa 420-441 (T⁴²⁰NINTTNQHI MLQNSSGIEKYN⁴⁴¹) of C-terminal human plasma PAF-acetylhydrolase.
SPECIFICITY:	Recognizes human plasma PAF-acetylhydrolase. Detects a band of ~45kDa by Western blot. Does not cross-react with mouse, guinea pig, dog or chicken PAF-acetylhydrolase.
APPLICATION:	Western Blot (1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Information

PAF-acetylhydrolase (PAF-AH) catalyzes the hydrolysis of the acetyl group at the sn-2 position of PAF to yield lyso-PAF and acetate, thereby inactivating PAF. Two main types of PAF-AH have been characterized, namely secreted (i.e. plasma) and intracellular enzymes, which are encoded on individual genes and share only 41% homology at the amino acid level [1-3]. Plasma PAF-AH is a 45kDa enzyme which is associated with the LDL fraction of plasma [2,4].

General Literature References

[1] Platelet-activating factor acetylhydrolases : D.M. Stafforini, et al.; J. Biol. Chem. 272, 17895 (1997) Abstract; Full Text
[2] Anti-inflammatory properties of a platelet-activating factor acetylhydrolase: L.W. Tjoelker, et al.; Nature 374, 549 (1995) Abstract
[3] cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase: K. Hattori, et al.; J. Biol. Chem. 271, 33032 (1996) Abstract; Full Text
[4] Human plasma platelet-activating factor acetylhydrolase. Purification and properties: D.M. Stafforini; J. Biol. Chem. 262, 4223 (1987) Abstract; Full Text

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Polyclonal Antibodies

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