ALEXIS Biochemicals: Polyclonal Antibody to PAR-4

ALX-210-248

Revised 23-Apr-08

Polyclonal Antibody to PAR-4
SYNONYMS	anti-Prostate Apoptosis Response Protein-4 PAb
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Cell Death / Apoptosis / Autophagy Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-248-C200		200 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Rat
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
FORMULATION:	Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 324-342 (CE³²⁴QLKQENKT LLKVVGQLTR³⁴²) of human PAR-4 (prostate apoptosis response protein-4).
SPECIFICITY:	Recognizes human and rat PAR-4. Detects a band of ~40kDa by Western blot.
APPLICATION:	Western Blot (2µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-165-044.

General Information

Prostate apotosis response-4 (PAR-4) is a leucine zipper domain protein that is widely expressed in diverse normal and cancerous cell types and tissues. It is known as a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal/immortalized cells. The cancer-specific proapoptotic fuction of PAR-4 is localized in its central core SAC domain. Y. Zhao, et al. characterized a novel mouse model with ubiquitous expression of the SAC domain. Their findings provided genetic evidence that the SAC domain of PAR-4 confers cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance. PAR-4 has also been observed at ~18 times higher concentration in human brain tissue from Alzheimer patients when compared to unaffected brain tissue.

General Literature References

Expression and function of the leucine zipper protein Par-4 in apoptosis: S.F. Sells, et al.; Mol. Cell Biol. 17, 3823 (1997) Abstract; Full Text
Cancer resistance in transgenic mice expressing the SAC module of Par-4: Y. Zhao, et al.; Cancer Res. 67, 9276 (2007) Abstract

Further Categories Containing This Product:

Polyclonal Antibodies • Cancer Other Products

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