ALEXIS Biochemicals: Polyclonal Antibody to Shc

ALX-210-535

Revised 31-Oct-06

Polyclonal Antibody to Shc
SYNONYMS	anti-Shc Transforming Protein 1 PAb anti-SH2 Domain Protein C1 PAb anti-Shc1 PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	SH2 & SH3 Domains

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-535-R100		100 µl	220.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
PURITY:	Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:	Recombinant human Shc portion (aa 1180-1620).
SPECIFICITY:	Recognizes human, mouse and hamster p46shc, p52shc and p66shc isoforms of phosphorylated and unphosphorylated Shc.
APPLICATION:	ELISA Immunoprecipitation Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

There are 3 alternatively spliced isoforms of the Shc adapter pro-tein: p46SHC, p52SHC and p66SHC, that link activated growth factor receptors to signalling pathway. Isoform p46SHC and p52SHC, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS com-plex and are implicated in mitogenic signalling. They function as initiators of the Ras signalling cascade in various non-neuronal systems. The isoform p66SHC does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. It acts as a downstream target of the tumor suppressor p53 and is indispen-sable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis.

Further Categories Containing This Product:

Shc & Other Ras Adaptors / Related Products • Phospho-specific Antibodies • Polyclonal Antibodies

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