ALEXIS Biochemicals: Polyclonal Antibody to SorLA (IC)

ALX-215-060

Revised 31-Jul-08

Polyclonal Antibody to SorLA (IC)
SYNONYMS	anti-LR11 PAb (IC) anti-SorL1 PAb (IC) anti-Sorting Protein-related Receptor Containing LDLR Class A Repeats PAb (IC) anti-Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats PAb (IC)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Neuropeptides & Receptors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-215-060-1		1 Vial	250.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
SOURCE/HOST:	From rabbit.
FORMULATION:	Lyophilized.
RECONSTITUTION:	Reconstitute with 50μl distilled water.
IMMUNOGEN:	Synthetic peptide corresponding to the 18 C-terminal aa from the intracellular tail (IC) of mouse SorLA with an added N-terminal cysteine.
SPECIFICITY:	Recognizes human, mouse and rat SorLA.
APPLICATION:	Immunocytochemistry (1:3’000) Western Blot (1:3’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	Blocking Peptide for PAb to SorLA Prod. No. ALX-167-028

Product Description

Recognizes transmembrane SorLA, the membrane stub after ectodomain shedding and also the soluble cytoplasmic domain.

Product Specific Literature References

Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator: W. Hampe, et al.; J. Cell Sci. 113, 4475 (2000) Abstract; Full Text
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA: J. Lintzel, et al.; Biol. Chem. 383, 1727 (2002) Abstract
SorLA signaling by regulated intramembrane proteolysis: C. Böhm, et al.; J. Biol. Chem. 281, 14547 (2006) Abstract; Full Text
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease: E. Rogaeva, et al.; Nat. Genet. 39, 168 (2007) Abstract

ALX-215-061	Polyclonal Antibody to SorLA (F3)
ALX-167-028	Blocking Peptide for PAb to SorLA (IC) (Prod. No. ALX-215-060)