ALEXIS Biochemicals: Polyclonal Antibody to SynGAP

ALX-210-269

Revised 13-Jan-05

Polyclonal Antibody to SynGAP
SYNONYMS	anti-Synaptic Ras-GTPase Activating Protein PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	GTPase-activating Proteins [GAPs]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-269-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse Rat
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
FORMULATION:	Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 947-1167 of rat SynGAP (synaptic Ras-GTPase activating protein).
SPECIFICITY:	Recognizes mouse and rat SynGAP. Detects a band of ~135kDa by Western blot.
APPLICATION:	Immunocytochemistry (1µg/ml) Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Description

SynGAP, synaptic Ras-GTPase activating protein, is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with PSD-95, a synaptic scaffold protein, and synaptic NMDA receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

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Polyclonal Antibodies

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