ALEXIS Biochemicals: Polyclonal Antibody to UCP-3

ALX-210-238

Revised 22-Sep-04

Polyclonal Antibody to UCP-3
SYNONYMS	anti-Uncoupling Protein-3 PAb
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Obesity & Diabetes Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-238-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Epitope affinity purified antibody in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 295-308 (R²⁹⁵ALMKVQVLRESPF³⁰⁸) of mouse and rat UCP-3 (mitochondrial uncoupling protein-3). This sequence differs from human and pig UCP-3 by a single amino acid substitution.
SPECIFICITY:	Recognizes human, mouse and rat UCP-3. Detects a band of ~30kDa by Western blot. Does not recognize UCP-3 from mouse liver or kidney.
APPLICATION:	Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-162-025.

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General Information

The uncoupling proteins are found in the inner mitochondrial membranes and belong to a family of mitochondrial anion transport proteins that include the PO4 and oxologutarate carriers, and the ADP/ATP translocator. Three UCP subtypes have been identified and cloned. UCP-1 is abundantly expressed in brown adipose tissue of mammals. UCP-1 allows H⁺ re-entry into the mitochondrial matrix without involving the F0-F1 ATPase which produces heat instead of ATP. It is thought that UCP-2 and 3 also dissipate the mitochondrial proton gradient produced by the respiratory chain in cells and tissues within which they are expressed. Studies have shown UCP-2 to be expressed by a variety of tissues. UCP-3 is expressed predominantly in brown adipose tissue, skeletal muscle, at lower levels in heart and smooth muscle, and is absent in liver and kidney.

General Literature References

The uncoupling proteins, a review : O. Boss, et al.; Eur. J. Endocrinol. 139, 1 (1998), (Review) Abstract
The mechanism of proton transport mediated by mitochondrial uncoupling proteins: K.D. Garlid, et al.; FEBS Lett. 438, 10 (1998), (Minireview) Abstract; Full Text

Further Categories Containing This Product:

Respiratory Chain Other Products • Polyclonal Antibodies

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