ALEXIS Biochemicals: Polyclonal Antibody to CCR1 (human)

ALX-210-620

Revised 25-Jan-07

Polyclonal Antibody to CCR1 (human)
SYNONYMS	anti-C-C Chemokine Receptor 1 (human) PAb anti-CD191 (human) PAb
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	CC Chemokines & Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-620-C200		200 µg	340.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From goat.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 7-24 (T⁷EDYDTTTEFDY GDATPC²⁴) of the N-terminal extracellular domain of human CCR1 (C-C chemokine receptor 1).
SPECIFICITY:	Recognizes human CCR1. Does not cross-react with mouse CCR1.
APPLICATION:	Immunocytochemistry (1:400) Western Blot (1:1’000)
QUALITY CONTROL:	Immunocytochemistry on human peripheral blood leukocytes.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-153-019.

Product Description

CCR1 is a receptor for macrophage inflammatory protein-1α (MIP-1α) and RANTES, expressed in peripheral blood lymphocytes and monocytes (but not neutrophils). The antibody is useful in determining the number of CCR1 positive cells and in detecting any changes in the level of CCR1 expression in cells present at the site of inflammation.

General Literature References

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor: K. Neote, et al.; Cell 72, 415 (1993) Abstract