ALEXIS Biochemicals: Polyclonal Antibody to Heme Oxygenase-1

ALX-210-116

Revised 15-May-06

Polyclonal Antibody to Heme Oxygenase-1
SYNONYMS	anti-HO-1 PAb
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Heme Oxygenase / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-116-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Monkey Others
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Neat serum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 1-30 (M¹ERPQLDSMSQDL SEALKEATKEVHIRAEN³⁰) of N-terminal rat HO-1 (heme oxygenase-1).
SPECIFICITY:	Recognizes human, mouse, rat, monkey and bovine HO-1. Detects a band of ~32kDa by Western blot. Does not cross-react with HO-2.
APPLICATION:	Immunohistochemistry (paraffin sections (1:100)) Western Blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease: M.A. Smith, et al.; Am. J. Pathol. 145, 42 (1994) Abstract
RT-PCR assay for heme oxygenase-1 and heme oxygenase-2: a sensitive method to estimate cellular oxidative damage: R.K. Kutty, et al.; Ann. N. Y. Acad. Sci. 738, 427 (1994) Abstract
Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta: R.K. Kutty, et al.; J. Cell. Physiol. 159, 371 (1994) Abstract
Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea: R.K. Kutty, et al.; PNAS 92, 1177 (1995) Abstract
Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion: A.C. Zenclussen, et al.; Scand. J. Immunol. 55, 560 (2002) Abstract
Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface: A. Sollwedel, et al.; J. Immunol. 175, 4875 (2005) Abstract
Heme oxygenase as a therapeutic target in immunological pregnancy complications: A.C. Zenclussen, et al.; Int. Immunopharmacol. 5, 41 (2005) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Immunohistochemical staining of HO-1 in Alzheimer's diseased human brain with Prod. No. ALX-210-116 results in staining of the neurofibrillary tangles, senile plaque neurites and neurophil threads.

Further Categories Containing This Product:

Polyclonal Antibodies

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.