ALEXIS Biochemicals: Polyclonal Antibody to Adenosine Receptor A1 (rat)

ALX-210-144/1

Revised 27-Dec-06

Polyclonal Antibody to Adenosine Receptor A1 (rat)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Adenosine Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-144/1-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Rat Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to the C-terminal aa 309-326 (C³⁰⁹QPKPPIDEDLPEEKAED³²⁶) of rat adenosine receptor A₁(A₁AR).
SPECIFICITY:	Recognizes rat adenosine receptor A₁. Detects a band of ~37kDa by Western blot. Does not cross-react with other adenosine receptors.
APPLICATION:	Western Blot: 1:500. Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A₁, A_2a, A_2b, A₃). Activation of ARs mediates several receptor subtype-specific physiological processes including cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.
The A₁AR is a glycoprotein of MW 36-40 kDa that can activate G_i and G_o proteins in vitro. In intact cells, agonist occupation of the A₁AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of K⁺ channels by A₁AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A₁AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A₁AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A₁AR including kidney and testis.

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Polyclonal Antibodies

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