ALEXIS Biochemicals: Polyclonal Antibody to O6-Methylguanine-DNA Methyltransferase

ALX-210-551

Revised 23-Feb-05

Polyclonal Antibody to O6-Methylguanine-DNA Methyltransferase
SYNONYMS	anti-O⁶-Methylguanine-DNA Methyltransferase PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	DNA Repair Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-551-R100		100 µl	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
SOURCE/HOST:	From rabbit.
FORMULATION:	Contains 0.05% sodium azide.
IMMUNOGEN:	Human MGMT (O⁶-methylguanine-DNA methyltransferase).
SPECIFICITY:	Recognizes human, mouse and rat MGMT.
APPLICATION:	Western Blot (1:100-1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Specific Literature References

O6-methylguanine-DNA methyltransferase activity in breast and brain tumors: I. Preuss, et al.; Int. J. Cancer 61, 321 (1995) Abstract

General Information

O⁶-Methylguanine-DNA methyltransferase (MGMT) removes O⁶-methylguanine from DNA by transferring the O⁶-alkyl group to a specific cysteine residue within its own sequence irreversibly inactivating MGMT. Unrepaired alkylated guanine will cause G·C -> A·T transition mutations by anomalous base pairing during DNA replication. DNA damage by O⁶-methylguanine can induce apoptosis regulated by Bcl-2 and caspases- 3 & -9. MGMT is able to remove O⁴-alkylated-thymine.

Further Categories Containing This Product:

DNA & RNA Methyl & Alkyl Transferases / Related Products • Polyclonal Antibodies

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