Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
> Protein Synthesis, Modification & Degradation
Autophagy / Related Products
Mono(ADP-ribosyl)transferases / Related Products
Ubiquitin & Proteasome
Posttranslational Modification
Protein Synthesis
Vesicles & Membrane Trafficking
Protein Synthesis, Modification & Degradation Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
1-20
of 594
Page 1
of 30
Select Page:
1
2
3
4
5
6
7
8
9
10
>>
ALX-430-155
Revised 16-Nov-07
4EGI-1
SYNONYMS
α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Translation Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-155-M002
2 mg
190.00 USD
Product Specification
FORMULA:
C
18
H
12
Cl
2
N
4
O
4
S
MW:
451.3
CAS NUMBER:
315706-13-9
PURITY:
≥95%
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Selective and cell permeable inhibitor of the interaction between the human eukaryotic translation initiation factors 4E (eIF4E) and 4G (eIF4G).
Product Specific Literature References
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G:
N.J. Moerke, et al.; Cell
128
, 257 (2007)
Abstract
ALX-430-096
Revised 24-Feb-05
A77 1726
SYNONYMS
N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide
2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-096-M005
5 mg
45.00 USD
ALX-430-096-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
12
H
9
F
3
N
2
O
2
MW:
270.2
CAS NUMBER:
108605-62-5
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Physiologically active metabolite of the immunosuppressive drug leflunomide (Prod. No.
ALX-430-095
). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of cyclooxygenase-2 (COX-2)
in vitro
and
in vivo
.
Product Specific Literature References
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide:
T. Mattar, et al.; FEBS Lett.
334
, 161 (1993)
Abstract
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide:
X. Xu, et al.; J. Biol. Chem.
270
, 12398 (1995)
Abstract
;
Full Text
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase:
J.P. Davis, et al.; Biochemistry
35
, 1270 (1996)
Abstract
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation:
X. Xu, et al.; Biochem. Pharmacol.
52
, 527 (1996)
Abstract
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms:
R.T. Elder, et al.; J. Immunol.
159
, 22 (1997)
Abstract
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice:
X. Xu, et al.; J. Immunol.
159
, 167 (1997)
Abstract
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression:
S.K. Manna & B.B. Aggarwal; J. Immunol.
162
, 2095 (1999)
Abstract
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner:
L.C. Hamilton, et al.; Br. J. Pharmacol.
127
, 1589 (1999)
Abstract
Further Categories Containing This Product:
COX Inhibitors
•
Immunomodulators Other Products
•
NF-kB Pathway Inhibitors
ALX-151-026
Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-026-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
39
H
57
N
7
O
14
S
MW:
880.0
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Phosphoinositide 3-kinase [PI(3)K] / Related Products
•
Peptides
ALX-151-027
Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-027-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
36
H
57
N
7
O
13
SP
MW:
858.9
PURITY:
≥96%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Phosphoinositide 3-kinase [PI(3)K] / Related Products
•
Peptides
ALX-350-310
Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
SYNONYMS
AKβBA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-310-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
32
H
48
O
5
MW:
512.7
CAS NUMBER:
67416-61-9
SOURCE/HOST:
Isolated from
Boswellia serrata.
PURITY:
≥99% (HPLC, NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No.
ALX-350-308
). Exhibits
in vivo
efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I:
R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther.
288
, 613 (1999)
Abstract
;
Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization:
A. Altmann, et al.; BBRC
290
, 185 (2002)
Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes:
A. Altmann, et al.; Br. J. Pharmacol.
141
, 223 (2004)
Abstract
;
Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
;
Full Text
Boswellic acids: biological actions and molecular targets:
D. Poeckel & O. Werz; Curr. Med. Chem.
13
, 3359 (2006), Review
Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis:
C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
290
, G1131 (2006)
Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid:
M. Bishnoi, et al.; Indian J. Exp. Biol.
44
, 128 (2006)
Abstract
Related Products
ALX-350-308
3-O-Acetyl-β-boswellic acid
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Topoisomerase Inhibitors
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Lipoxygenases / Related Products
ALX-480-021
Revised 16-Dec-04
Adenosine 5'-triphosphate . disodium salt
SYNONYMS
ATP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-021-G001
1 g
15.00 USD
ALX-480-021-G005
5 g
45.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
13
P
3
. 2Na
MW:
505.2 . 46.0
CAS NUMBER:
51963-61-2
MERCK INDEX:
14:
155
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture. Keep cool and dry.
Further Categories Containing This Product:
Inflammasome
ALX-270-385
Revised 17-Jul-07
Aloisine A
SYNONYMS
RP107
7-
n
-Butyl-6-(4-hydroxyphenyl)[5
H
]pyrrolo[2,3-
b
]pyrazine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-385-M001
1 mg
30.00 USD
Product Specification
FORMULA:
C
16
H
17
N
3
O
MW:
267.3
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Cell permeable, potent, selective, reversible and ATP-competitive inhibitor of CDK1/cyclin B (IC
50
=150nM), CDK2/cyclin A (IC
50
=120nM), CDK2/cyclin E (IC
50
=400nM), CDK5/p25
(IC
50
=200nM), CDK5/p35 (IC
50
=160nM) and GSK-3α (IC
50
=500nM). Also inhibits GSK-3β (IC
50
=650nM) and c-Jun N-terminal kinase (JNK) (IC
50
~3-10µM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC
50
≥100µM). Blocks cell cycle in both G1 and G2 phase.
Product Specific Literature References
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
:
Y. Mettey, et al.; J. Med. Chem.
46
, 222 (2003)
Abstract
Further Categories Containing This Product:
GSK-3 Inhibitors
•
JNK [SAPK1] / Related Products
•
Cell Cycle Blockers & Inhibitors / Related Products
ALX-350-270
Revised 08-Feb-08
α-Amanitin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-270-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
39
H
54
N
10
O
14
S
MW:
919.0
CAS NUMBER:
23109-05-9
MERCK INDEX:
14:
373
RTECS:
BD6195000
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥90%
APPEARANCE:
White to light yellow powder.
SOLUBILITY:
Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.
Product Specific Literature References
Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver:
F. Stirpe & L. Fiume; Biochem. J.
103
, 67P (1967)
Abstract
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin:
T.J. Lindell, et al.; Science
170
, 447 (1970)
Abstract
Fifty years of amanitin:
T. Wieland & H. Faulstich; Experientia
47
, 1189 (1991), (Review)
Abstract
Alpha-amanitin blocks translocation by human RNA polymerase II:
X.Q. Gong, et al.; J. Biol. Chem.
279
, 27422 (2004)
Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products
•
Protein Synthesis Other Products
•
RNA Polymerases / Related Products
ALX-350-271
Revised 08-Oct-07
β-Amanitin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-271-M001
1 mg
170.00 USD
Product Specification
FORMULA:
C
39
H
53
N
9
O
15
S
MW:
920.0
CAS NUMBER:
21150-22-1
MERCK INDEX:
14:
373
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥90%
FORMULATION:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Biological activity like α-amanitin (Prod. No.
ALX-350-270
), but contains a carboxy group which is useful for coupling reactions.
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products
•
Protein Synthesis Other Products
•
RNA Polymerases / Related Products
ALX-350-272
Revised 17-Dec-07
γ-Amanitin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-272-M001
1 mg
170.00 USD
Product Specification
FORMULA:
C
39
H
54
N
10
O
13
S
MW:
903.0
CAS NUMBER:
13567-11-8; 21150-23-2
MERCK INDEX:
14:
373
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥90%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Biological activity like α-amanitin (Prod. No.
ALX-350-270
).
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products
•
Protein Synthesis Other Products
•
RNA Polymerases / Related Products
ALX-430-110
Revised 16-Jan-08
5-Aminosalicylic acid
SYNONYMS
5-ASA
Mesalamine
5-Amino-2-hydroxybenzoic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
