ALEXIS Biochemicals: Progranulin (human) (recombinant)

ALX-201-377

Revised 06-May-08

Progranulin (human) (recombinant)
SYNONYMS	Proepithelin (human) (recombinant) PEPI (human) (recombinant) PC Cell-derived Growth Factor (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	Progranulin/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-377-C010		10 µg	180.00 USD
ALX-201-377-C050		50 µg	480.00 USD

Product Specification

SOURCE/HOST:	Produced in HEK 293 cells. Signal peptide and mature human progranulin (aa 1-593) is fused at the C-terminus to a FLAG^®-tag.
CONCENTRATION:	1mg/ml
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg protein (LAL-test).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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General Information

Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link P28799: Granulins (human) [Precursor] FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by AdipoGen, Inc.

General Literature References

Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract

Further Categories Containing This Product:

Inflammation Other Products • Recombinant Proteins/Fusion Proteins

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