ALEXIS Biochemicals: Proscillaridin A

ALX-350-285

Revised 19-Feb-08

Proscillaridin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - ATPase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-285-M005		5 mg	17.00 USD

Product Specification

FORMULA:	C₃₀H₄₂O₈
MW:	530.7
CAS NUMBER:	466-06-8
RTECS:	UK6650000
PURITY:	≥90%
APPEARANCE:	White to light yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.
IDENTITY:	Determined by IR.

Product Description

Cardiac glycoside. Specific Na⁺/K⁺-ATPase inhibitor. Shows high cytotoxicity in tumor cells. Very potent immunosuppressor. DNA topoisomerase I & II inhibitor.

Product Specific Literature References

Clinical studies on proscillaridin a new squill glycoside: L. Gould, et al.; J. Clin. Pharmacol. New Drugs 11, 135 (1971) Abstract
Proscillaridin A immunoreactivity: a new endogenous cardiac glycoside?: S.Q. Li, et al.; Ann. N Y Acad. Sci. 834, 646 (1997) Abstract
Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells: S. Johansson, et al.; Anticancer Drugs 12, 475 (2001) Abstract
Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A: K. Bielawski, et al.; Biol. Pharm. Bull. 29, 1493 (2006) Abstract
Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells: K. Winnicka, et al.; Arch. Pharm. Res. 30, 1216 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Topoisomerase Inhibitors • Na+ / K+-ATPase / Related Products • Natural Products - Immunomodulators

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