ALEXIS Biochemicals: Protoporphyrin IX (free acid)

ALX-430-041

Revised 17-Sep-08

Protoporphyrin IX (free acid)
SYNONYMS	8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Porphyrins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-041-M300		300 mg	50.00 USD
ALX-430-041-G001		1 g	90.00 USD

Product Specification

FORMULA:	C₃₄H₃₄N₄O₄
MW:	562.6
CAS NUMBER:	553-12-8
MERCK INDEX:	14: 7897
PURITY:	≥97% (HPLC)
APPEARANCE:	Purple to dark brown solid.
SOLUBILITY:	Soluble in conc. HCl, DMSO (10mg/ml) or 100% ethanol (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by NMR.

Product Description

Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable.

Product Specific Literature References

H. Verweij & J. Van Steveninck; Photochem. Photobiol. 35, 265 (1982)
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme: M.S. Wolin, et al.; J. Biol. Chem. 257, 13312 (1982) Abstract; Full Text
Porphyrins and chlorophylls as probes for fluoroimmunoassays [letter]: J.L. Hendrix; Clin. Chem. 29, 1003 (1983) Abstract
Photodynamic intramolecular crosslinking of myoglobin: J. van Steveninck and T.M.A.R. Dubbelman; Biochim. Biophys. Acta 791, 98 (1984)

Further Categories Containing This Product:

Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.