ALEXIS Biochemicals: Protoporphyrin IX (free acid)

ALX-430-041

Revised 25-May-07

Protoporphyrin IX (free acid)
SYNONYMS	8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Porphyrins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-041-M300		300 mg	50.00 USD
ALX-430-041-G001		1 g	90.00 USD

Product Specification

FORMULA:	C₃₄H₃₄N₄O₄
MW:	562.6
CAS NUMBER:	553-12-8
MERCK INDEX:	14: 7897
APPEARANCE:	Purple solid.
SOLUBILITY:	Soluble in conc. HCl.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable.

Product Specific Literature References

H. Verweij & J. Van Steveninck; Photochem. Photobiol. 35, 265 (1982)
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme: M.S. Wolin, et al.; J. Biol. Chem. 257, 13312 (1982) Abstract; Full Text
Porphyrins and chlorophylls as probes for fluoroimmunoassays [letter]: J.L. Hendrix; Clin. Chem. 29, 1003 (1983) Abstract
Photodynamic intramolecular crosslinking of myoglobin: J. van Steveninck and T.M.A.R. Dubbelman; Biochim. Biophys. Acta 791, 98 (1984)

Further Categories Containing This Product:

Guanylyl Cyclases, Guanosine Phosphate Metabolism/Related Products

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