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ALX-350-276 Revised 16-Jun-08
Pseudohypericin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-276-M001   1 mg 115.00 USD Add To Cart
ALX-350-276-M005   5 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C30H16O9
MW: 520.5
CAS NUMBER: 55954-61-5
SOURCE/HOST: Isolated from Hypericum perforatum.
PURITY: ≥98%
APPEARANCE: Black to black-red powder.
SOLUBILITY: Soluble in methanol, 100% ethanol, DMSO, acetone and other organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of protein kinase C (PKC) (IC50=15µg/ml). Antiviral and antiretroviral activity. Potent inhibitor of dopamine-β-hydrolase (IC50=3µg/ml).
Product Specific Literature References
Zur Isolierung und Konstitution des Pseudohypericins : H. Brockmann, et al.; Tetrahedron Lett. 15, 1991 (1974)
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin: D. Meruelo, et al.; PNAS 85, 5230 (1988) Abstract
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin: G. Lavie, et al.; PNAS 86, 5963 (1989) Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989) Abstract
Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids: A. Denke, et al.; Arzneimittelforschung 50, 415 (2000) Abstract
Antagonist effect of pseudohypericin at CRF1 receptors: U. Simmen, et al.; Eur. J. Pharmacol. 458, 251 (2003) Abstract
Phototoxic and apoptosis-inducing capacity of pseudohypericin: C.M. Schempp, et al.; Planta Med. 68, 171 (2002) Abstract
Further Categories Containing This Product:
PKC Inhibitors • Natural Products - Antiviral / anti-HIV Agents • Natural Products for Neurological Research • Neuroactive Agents Other Products
 
 
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