ALEXIS Biochemicals: Psoralen

ALX-350-364

Revised 08-Apr-08

Psoralen
SYNONYMS	Ficusin 7H-Furo[3,2-g]benzopyran-7-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products with Antibiotic Activity

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-364-M025		25 mg	95.00 USD
ALX-350-364-M100		100 mg	285.00 USD

Product Specification

FORMULA:	C₁₁H₆O₃
MW:	186.2
CAS NUMBER:	66-97-7
MERCK INDEX:	14: 7928
RTECS:	LV0944000
SOURCE/HOST:	Isolated from Psoralea corylifolia.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in ethyl acetate or acetone; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE MUTAGENIC. HARMFUL.

Product Description

Shows antiviral, antibacterial, antifungal and insecticidal properties. Binds DNA through single and double-stranded cross-linking after photoactivation. Used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.

Product Specific Literature References

Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig: A. Kornhauser, et al.; Science 217, 733 (1982) Abstract
Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry: G.D. Cimino, et al.; Annu. Rev. Biochem. 54, 1151 (1985), (Review) Abstract
Electron microscopic identification of supercoiled regions in complex DNA structures: R.B. Inman & M. Schnos; J. Mol. Biol. 193, 377 (1987) Abstract
Probing DNA structure with psoralen in vitro: D.W. Ussery, et al.; Meth. Enzymol. 212, 242 (1992) Abstract
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria: C. Cullinane & V.A. Bohr; Cancer Res. 58, 1400 (1998) Abstract; Full Text
Psoralen photocrosslinking, a tool to study the chromatin structure of RNA polymerase I--transcribed ribosomal genes: M. Toussaint, et al.; Biochem. Cell Biol. 83, 449 (2005) Abstract
Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells: S. Couve-Privat, et al.; Nucl. Acids Res. 35, 5672 (2007) Abstract; Full Text
Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids: K.H. Kim, et al.; Nucl. Acids Res. 35, 7604 (2007) Abstract; Full Text

Further Categories Containing This Product:

Natural Products - Antiviral/anti-HIV Agents • Natural Products - Antifungal Agents • DNA Intercalators & Crosslinkers • Pesticides/Related Products

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