ALEXIS Biochemicals: Puerarin

ALX-350-249

Revised 07-Oct-08

Puerarin
SYNONYMS	8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one NPI-031G
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-249-M005		5 mg	110.00 USD

Product Specification

FORMULA:	C₂₁H₂₀O₉
MW:	416.4
CAS NUMBER:	3681-99-0
RTECS:	UO5216000
SOURCE/HOST:	Isolated from Kudzu root.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Biologically active isoflavone. Affects serotonin levels and platelet aggregation in blood cells. Is a 5-HT2c antagonist. Antibacterial. Displays cardioprotective effects. Induces apoptosis.

Product Specific Literature References

Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria: W.M. Keung & B.L. Vallee; PNAS 95, 2198 (1998) Abstract
Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity: D.H. Kim, et al.; Biol. Pharm. Bull. 21, 628 (1998) Abstract
NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists: D.H. Overstreet, et al.; Pharmacol. Biochem. Behav. 75, 619 (2003) Abstract
Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells: C.P. Mao & Z.L. Gu; Acta Pharmacol. Sin. 26, 982 (2005) Abstract
Contrasting effects of puerarin and daidzin on glucose homeostasis in mice: E. Meezan, et al.; J. Agric. Food Chem. 53, 8760 (2005) Abstract
Induction of apoptosis by puerarin in colon cancer HT-29 cells: Z. Yu & W. L; Cancer Lett. 238, 53 (2006) Abstract
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin: 574, 179 (2007)
: Q. Gao, et al.; Eur. J. Pharmacol. 574, 179 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Apoptosis Inducers & Inhibitors • Flavonoids / Related Products • Natural Products with Antibiotic Activity • Natural Products for Neurological Research • Serotonergics & Serotonin Receptors / Related Products

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