ALEXIS Biochemicals: Pyrrolidinedithiocarbamic acid . ammonium salt

ALX-400-002

Revised 15-May-08

Pyrrolidinedithiocarbamic acid . ammonium salt
SYNONYMS	Ammoniumpyrrolidinedithiocarbamate Ammoniumtetramethylenedithiocarbamate
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-002-G005		5 g	29.00 USD
ALX-400-002-G025		25 g	55.00 USD

Product Specification

FORMULA:	C₅H₈NS₂ . NH₄
MW:	146.3 . 18.0
CAS NUMBER:	5108-96-3
PURITY:	≥98%
APPEARANCE:	White to-off white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Inhibitor of NF-κB activation (induced by either PMA or TNF-α) in various cell types.

Product Specific Literature References

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells: R. Schreck, et al.; J. Exp. Med. 175, 1181 (1992) Abstract
Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes: H.W. Ziegler-Heitbrock, et al.; J. Immunol. 151, 6986 (1993) Abstract
Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages: M.P. Sherman, et al.; BBRC 191, 1301 (1993) Abstract
Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells: W. Eberhardt, et al.; BBRC 200, 163 (1994) Abstract
In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation: T.S. Blackwell, et al.; Immunol. 157, 1630 (1996) Abstract
In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock: S.F. Liu, et al.; J. Immunol. 159, 3976 (1997) Abstract
Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation: C.H. Kim, et al.; FEBS Lett. 449, 28 (1999) Abstract
Dual activity of pyrrolidine dithiocarbamate on kappa B-dependent gene expression in U937 cells: I. Regulation by the phorbol ester TPA: K. Watanabe, et al.; Cell Signal 11, 479 (1999) Abstract
Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes: S.F. Liu, et al.; Circulation 100, 1330 (1999) Abstract
Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: II. Regulation by tumour necrosis factor- alpha: K. Watanabe, et al.; Cell Signal 11, 371 (1999) Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem Biophys Res Commun 276, 88 (2000) Abstract

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