ALEXIS Biochemicals: R-(+)-Baclofen . hydrochloride

ALX-550-074

Revised 30-Sep-08

R-(+)-Baclofen . hydrochloride
SYNONYMS	R-(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid . HCl R-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid . HCl
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	GABA-ergics & GABA Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-074-M010		10 mg	45.00 USD
ALX-550-074-M050		50 mg	170.00 USD

Product Specification

FORMULA:	C₁₀H₁₂ClNO₂ . HCl
MW:	213.7 . 36.5
CAS NUMBER:	63701-55-3
MERCK INDEX:	14: 937
RTECS:	MW5084350
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water, dilute aqueous base or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Selective GABA_B receptor agonist. Skeletal muscle relaxant. The more active enantiomer of (±)-Baclofen (Prod. No. ALX-550-039).

Product Specific Literature References

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity: B. Witczuk, et al.; Pol. J. Pharmacol. Pharm. 32, 187 (1980) Abstract
Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations: E. Falch, et al.; J. Neurochem. 47, 898 (1986) Abstract
Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat: Y.G. Hong & J.L. Henry; Eur. J. Pharmacol. 196, 267 (1991) Abstract
Effects of GABA(B) receptor ligands in animal tests of depression and anxiety: M. Frankowska, et al.; Pharmacol. Rep. 59, 645 (2007) Abstract
A novel cause of intrathecal baclofen overdosage: lessons to be learnt: C. Dalton, et al.; Clin. Rehabil. 22, 188 (2008) Abstract
Skeletal muscle relaxants: S. See & R. Ginzburg; Pharmacotherapy 28, 207 (2008) Abstract

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