ALEXIS Biochemicals: RAIDD (human) (recombinant)

ALX-522-085

Revised 21-Dec-06

RAIDD (human) (recombinant)
SYNONYMS	CRADD (human) (recombinant) Caspase and RIP Adaptor with Death Domain (human) (recombinant) RIP-associated Protein with a Death Domain (human) (recombinant)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	RAIDD / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-085-C050		50 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
MW:	~48kDa (SDS-PAGE).
SOURCE/HOST:	Produced in E. coli. Full length human RAIDD (aa 1-199) is fused to a N-terminal tag.
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
APPLICATION:	Use as positive control for the PAb to RAIDD (human) (AT100) (Prod. No. ALX-210-915).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Information

RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. In human cell lines, the caspase-2 adaptor RAIDD interacts selectively with caspase-2 through its caspase recruitment domain (CARD) and leads to caspase-2-dependent death. RAIDD overexpression induced caspase-2, CARD- and caspase-9-dependent apoptosis of PC12 cells and sympathetic neurons. Apoptosis correlated with the formation of discrete perinuclear aggregates. Both death and aggregates required the expression of full-length RAIDD. Recently, it has been reported that activation of caspase-2 occurs in a complex that contains the death domain–containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress: A. Tinel and J. Tschopp; Science 304, 843 (2004) Abstract
RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons: O. Jabado, et al.; Cell Death Differ. 11, 618 (2004) Abstract

Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins

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