ALEXIS Biochemicals: RGMC, Soluble (human) (recombinant)

ALX-522-104

Revised 27-Mar-08

RGMC, Soluble (human) (recombinant)
SYNONYMS	Repulsive Guidance Molecule C, Soluble (human) (recombinant) Hemojuvelin, Soluble (human) (recombinant) Hemochromatosis Type 2 Protein, Soluble (human) (recombinant) HFE2, Soluble (human) (recombinant)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Dependence Receptors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-104-C010		10 µg	290.00 USD

Product Specification

SOURCE/HOST:	Produced in HEK 293 cells. The domain of human RGMC (36-398) is fused at the N-terminus to a linker peptide (8aa) and a FLAG^®-tag.
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

General Information

The RGMC (also called Hemojuvelin) is an GPI-anchored protein involved in the iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q6ZVN8: Repulsive Guidance Molecule C (human) (Precursor) FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

RGM and its receptor neogenin regulate neuronal survival: E. Matsunaga, et al.; Nat. Cell Biol. 6, 749 (2004) Abstract
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload: V. Niederkofler, et al.; J. Clin. Invest. 115, 2180 (2005) Abstract
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression: J.L. Babitt, et al.; Nat. Genet. 38, 531 (2006) Abstract

Further Categories Containing This Product:

Recombinant Proteins/Fusion Proteins • Bone Morphogenetic Proteins [BMPs] & Receptors/Related Products • Growth, Survival and Development of Neurons Other Products

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