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ALX-620-009 Revised 24-May-07
RHOD 2/AM
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SYNONYMS 1-[2-Amino-5-(3-dimethylamino-6-dimethylammonio-9-xanthenyl)phenoxy]-2-(2-amino-5-methylphenoxy)]ethane-N,N,N’,N’-tetraacetic acid, tetraacetoxy methyl ester . Br
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calcium Chelators / Caged Calcium Chelators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-009-M001   1 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C52H59N4O19 . Br
MW: 1044.1 . 79.9
CAS NUMBER: 129787-64-0
PURITY: ≥90% (HPLC)
APPEARANCE: Red solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.

Product Description
Membrane permeable form of RHOD 2 (Prod. No. ALX-620-008). Fluorescent probe for intracellular Ca2+.
Product Specific Literature References
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores: A. Minta, et al.; J. Biol. Chem. 264, 8171 (1989) Abstract; Full Text
Effects of the N-methyl-D-aspartate antagonists on the rise in [Ca2+]i following depolarization in aged rat brain synaptosomes: M. Okada, et al.; Brain Res. 584, 227 (1992) Abstract
Cyclic AMP-dependent phosphorylation of the inositol-1,4,5- trisphosphate receptor inhibits Ca2+ release from platelet membranes: T.M. Quinton & W.L. Dean; BBRC 184, 893 (1992) Abstract
Mechanisms of cholecystokinin-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity: Y. Tamura, et al.; Brain Res. 592, 317 (1992) Abstract
Confocal microscopy reveals coordinated calcium fluctuations and oscillations in synaptic boutons: N. Melamed, et al.; J. Neurosci. 13, 632 (1993) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Membrane permeable form may be loaded into cells directly via incubation. A mild detergent (e.g. Pluronic F-127) may be used to facilitate the loading process. RHOD 2/AM itself does not bind Ca2+, but once inside the cell it is readily hydrolyzed to RHOD 2 by endogenous esterases.

Includes 1 vial of Pluronic® (F127).
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Calcium Indicators / Probes • MDR Other Products
 
 
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