ALEXIS Biochemicals: RHOD 2 . triammonium salt

ALX-620-008

Revised 22-Dec-06

RHOD 2 . triammonium salt
SYNONYMS	1-[2-Amino-5-(3-dimethylamino-6-dimethylammonio-9-xanthenyl)phenoxy]-2-(2-amino-5-methylphenoxy)]ethane-N,N,N',N'-tetraacetic acid . 3NH₄⁺
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calcium Chelators/Caged Calcium Chelators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-620-008-M001		1 mg	190.00 USD

Product Specification

FORMULA:	C₄₀H₃₉N₄O₁₁ . 3NH₄⁺
MW:	751.7 . 54.1
CAS NUMBER:	129787-65-1
PURITY:	≥90%
SOLUBILITY:	Soluble in water (pH >6) or DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and moisture.

Product Description

A cell impermeable, UV excitable Ca²⁺-specific fluorophore. Can be loaded into cells via microinjection or scrape loading. Excitation and emission spectra do not undergo a shift and the sensor is essentially nonfluorescent before Ca²⁺-binding but becomes more fluorescent with increasing Ca²⁺ concentration. Due to its longer λmax. the product is useful for applications where autofluoresence is a problem, or where another fluorescent dye of shorter λmax. is used at the same time. Fluorescent enhancement from low to high [Ca²⁺] was smaller than that for FLUO 3 (Prod. No. ALX-620-002), and also in general the fluorescence is somewhat less than of FLUO 3.

Product Specific Literature References

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores: A. Minta, et al.; J. Biol. Chem. 264, 8171 (1989) Abstract; Full Text
Effects of the N-methyl-D-aspartate antagonists on the rise in [Ca2+]i following depolarization in aged rat brain synaptosomes: M. Okada, et al.; Brain Res. 583, 227 (1992) Abstract
Cyclic AMP-dependent phosphorylation of the inositol-1,4,5- trisphosphate receptor inhibits Ca2+ release from platelet membranes: T.M. Quinton & W.L. Dean; BBRC 184, 893 (1992) Abstract
Mechanisms of cholecystokinin-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity: Y. Tamura, et al.; Brain Res. 592, 317 (1992) Abstract
Confocal microscopy reveals coordinated calcium fluctuations and oscillations in synaptic boutons: N. Melamed, et al.; J. Neurosci. 13, 632 (1993) Abstract

Further Categories Containing This Product:

MDR Other Products • Dyes/Stains/Fluorescent Probes/Fluorescent Labels • Calcium Indicators/Probes

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