ALEXIS Biochemicals: RITA

ALX-430-151

Revised 18-Jun-07

RITA
SYNONYMS	Reactivation of p53 and Induction of Tumor Cell Apoptosis 2,5-bis(5-Hydroxymethyl-2-thienyl)furan NSC652287
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	p53 Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-151-M001		1 mg	75.00 USD
ALX-430-151-M005		5 mg	290.00 USD

Product Specification

FORMULA:	C₁₄H₁₂O₃S₂
MW:	292.4
CAS NUMBER:	213261-59-7
PURITY:	≥98%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol (1mg/ml), DMSO (20mg/ml), dimethyl formamide (30mg/ml); sparingly soluble in a 1:1 mixture of dimethyl formamide: PBS, pH 7.2 (0.5mg/ml).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least two years after receipt when stored at -20°C. For maximum solubility in aqueous buffers, first dissolve in dimethyl formamide and then dilute with the aqueous buffer of choice. We do not recommend storing the aqueous solution for more than one day.

Product Description

Inhibitor of p53/HDM2 interaction. Activator of p53 function in tumors. Potently inhibits the growth of a variety of cancer cell lines in the submicromolar range. It has been suggested that RITA selectively targets cells expressing p53 by other mechanisms than direct binding to the N-terminal domain of p53 [4].

Product Specific Literature References

[1] DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells: W. Nieves-Neira, et al.; Mol. Pharmacol. 56, 478 (1999) Abstract; Full Text
[2] Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism: M.I. Rivera, et al.; Biochem. Pharmacol. 57, 1283 (1999) Abstract
[3] Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors: N. Issaeva, et al.; Nat. Med. 10, 1321 (2004) Abstract
[4] NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro: M. Krajewski, et al.; Nat. Med. 11, 1135 (2005) Abstract

Further Categories Containing This Product:

Antitumor Agents (Apoptosis Inducers)

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