ALEXIS Biochemicals: RO-3306

ALX-270-463

Revised 22-Apr-08

RO-3306
SYNONYMS	(5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-463-M001		1 mg	50.00 USD
ALX-270-463-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₈H₁₃N₃OS₂
MW:	351.4
CAS NUMBER:	872573-93-8
PURITY:	≥95% (¹H-NMR)
APPEARANCE:	Brown solid.
SOLUBILITY:	Soluble in DMSO (5mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C in the dark.
HANDLING:	Protect from light.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Inhibitor of CDK1/cyclin B1 and CDK1/cyclin A. Reversibly arrests human cells at the G₂/M border of the cell cycle. Allows for effective cell synchronisation in early mitosis.

Product Specific Literature References

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1: L.T. Vassilev, et al.; PNAS 103, 10660 (2006) Abstract; Full Text
Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1: L.T. Vassilev; Cell Cycle 5, 2555 (2006) Abstract; Full Text

Further Categories Containing This Product:

Cell Cycle Blockers & Inhibitors / Related Products

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