ALEXIS Biochemicals: (RS)-4-Bromo-homo-ibotenic acid

ALX-550-155

Revised 28-Jan-05

(RS)-4-Bromo-homo-ibotenic acid
SYNONYMS	Br-HIBO (RS)-α-Amino-4-bromo-3-hydroxy-5-isoazolepropionic acid
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Glutamate Receptors (Metabotropic) / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-155-M005		5 mg	70.00 USD

Product Specification

FORMULA:	C₆H₇N₂O₄Br
MW:	251.0
CAS NUMBER:	71366-32-0
PURITY:	≥98%
APPEARANCE:	White crystalline powder.
SOLUBILITY:	Soluble in dilute aqueous base.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Potent AMPA receptor agonist. Selective but relatively non-potent group I mGluR agonist.

Product Specific Literature References

Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid: J.J. Hansen, et al.; J. Med. Chem. 32, 2254 (1989) Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990) Abstract
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane- 1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices: D.S. Chung, et al.; J. Neurochem. 63, 133 (1994) Abstract
Effects of bromohomoibotenate on metabotropic glutamate receptors: C. Thomsen, et al.; Neuroreport 5, 2417 (1994) Abstract
4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis: D.S. Chung, et al.; J. Pharmacol. Exp. Ther. 283, 742 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract

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AMPA Receptors / Related Products

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