ALEXIS Biochemicals: (R,S)-ATPA

ALX-550-352

Revised 17-Dec-04

(R,S)-ATPA
SYNONYMS	(R,S)-α-Amino-3-hydroxy-5-t-butyl-4-isoxazolepropionic acid
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Kainate Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-352-M001		1 mg	30.00 USD
ALX-550-352-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₁₀H₁₆N₂O₄
MW:	228.3
CAS NUMBER:	140158-50-5
PURITY:	≥97%
APPEARANCE:	White crystalline powder.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Potent and selective agonist of the GluR5 subtype of the kainate receptor.

Product Specific Literature References

Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors: J. Lauridsen, et al.; J. Med. Chem. 28, 668 (1985) Abstract
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission: V.R. Clarke, et al.; Nature 389, 599 (1997) Abstract
Pharmacological profile of the isomers of the GluR-specific agonist ATPA: K. Curry & H. Pajouhesh; Can. J. Physiol. Pharmacol. 76, 690 (1998) Abstract
Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord: M.J. Procter, et al.; Neuropharmacology 37, 1287 (1998) Abstract
The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus: M. Vignes, et al.; Neuropharmacology 37, 1269 (1998) Abstract

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