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ALX-550-054 Revised 28-Jan-05
(RS)-MCPG
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SYNONYMS (RS)-α-Methyl-4-carboxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-054-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C10H11NO4
MW: 209.2
CAS NUMBER: 146669-29-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base. Insoluble in water, ethanol, DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Specific Literature References
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors: Z.I. Bashir, et al.; Nature 363, 347 (1993) Abstract
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine: S.A. Eaton, et al.; Eur. J. Pharmacol. 244, 195 (1993) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation: J.J. O'Connor, et al.; Nature 367, 557 (1994) Abstract
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1: C. Joly, et al.; J. Neurosci. 15, 3970 (1995) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo: S.J. Martin & R.G. Morris; Neuropharmacology 36, 1339 (1997) Abstract
Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist: C. Wilson, et al.; Acta. Crystallogr. C 53 ( Pt 7), 909 (1997) Abstract
The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats: J.H. Kim & P. Vezina; Neuropharmacology 37, 189 (1998) Abstract
Inhibition of group I metabotropic glutamate receptors blocks spatial learning in rats: D. Balschun & W. Wetzel; Neurosci. Lett. 249, 41 (1998) Abstract
(+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor: N.A. Breakwell, et al.; J. Neurophysiol. 79, 1270 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 

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