ALEXIS Biochemicals: Ratjadone A (synthetic)

ALX-270-346

Revised 28-May-08

Ratjadone A (synthetic)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Cell Cycle Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-346-C002		2 µg	150.00 USD

Product Specification

FORMULA:	C₂₈H₄₀O₅
MW:	456.6
CAS NUMBER:	163564-92-9
SOURCE/HOST:	Synthetic.
PURITY:	≥95%
FORMULATION:	Liquid. Solution in methanol.
SOLUBILITY:	Soluble in methanol (20mg/ml) or aqueous buffers (<100µM).
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Sensitive to acids and bases. Unstable in acidic buffer systems (pH<6). Stable in substance as oil and in solution in methanol at -20°C.
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Represents a new class of natural compounds, which inhibit proliferation in eukaryotes by blocking nuclear export. As potent as leptomycin B (Prod. No. ALX-380-100) and specific for G1/S checkpoint. Cytotoxic secondary metabolite (IC₅₀=50pg/ml in mouse cell line L929) that arrests tumor cells in the G1 phase at remarkably low concentrations (50pg/ml in HeLa cell line KB3.1). Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound. Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds.

Product Specific Literature References

Antibiotics from gliding bacteria, LXIII. Ratjadone: a new antifungal metabolite from Sorangium cellulosum: D. Schummer, et al.; Liebigs Ann. 685 (1995)
Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physio-chemical and biological properties: J. Gerth, et al.; J. Antibiot. 48, 973 (1995) Abstract
The chemistry and biology of ratjadone: M. Kalesse, et al.; ChemBioChem. 9, 709 (2001) Abstract
The chemistry and biology of the leptomycin family: M. Kalesse & M. Christmann; Synthesis 8, 981 (2002) Abstract
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms: T. Meissner, et al.; FEBS Lett. 576, 27 (2004)
Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export: S. Strunze, et al.; Mol. Biol. Cell 16, 2999 (2005) Abstract

Further Categories Containing This Product:

Cell Cycle Blockers & Inhibitors/Related Products • Nuclear Envelope & Nuclear Transport • Antibiotics - Antifungal • Antitumor Antibiotics • Antitumor Agents (Anti-proliferative)

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