ALEXIS Biochemicals: Rebeccamycin

ALX-380-079

Revised 08-Apr-08

Rebeccamycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-079-C250		250 µg	120.00 USD
ALX-380-079-M001		1 mg	360.00 USD

Product Specification

FORMULA:	C₂₇H₂₁Cl₂N₃O₇
MW:	570.4
CAS NUMBER:	93908-02-2
SOURCE/HOST:	Isolated from Streptomyces sp.
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Protect from light.

Product Description

Antibiotic. Weak topoisomerase I inhibitor structurally similar to staurosporine (Prod. No. ALX-380-014). Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC₅₀=480nM against mouse B16 melanoma cells and IC₅₀=500nM against P388 leukemia cells).

Product Specific Literature References

Production and biological activity of rebeccamycin, a novel antitumor agent: J.A. Bush, et al.; J. Antibiot. (Tokyo) 40, 668 (1987) Abstract
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group: F. Anizon, et al.; J. Med. Chem. 40, 3456 (1997) Abstract
DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin: C. Bailly, et al.; Biochemistry 36, 3917 (1997) Abstract
Calories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition: C. Bailly, et al.; Chem. Biol. 6, 277 (1999) Abstract

Further Categories Containing This Product:

Antitumor Agents (Enzyme Inhibitors) • Antibiotics - Topoisomerase Inhibitors

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