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ALX-550-179 Revised 11-Apr-08
Resiniferatoxin (high purity)
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SYNONYMS RTX (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-179-M001   1 mg 45.00 USD Add To Cart
ALX-550-179-M005   5 mg 180.00 USD Add To Cart
ALX-550-179-M050   50 mg 1'200.00 USD Add To Cart
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Product Specification
FORMULA: C37H40O9
MW: 628.7
CAS NUMBER: 57444-62-9
RTECS: CY1633700
SOURCE/HOST: Isolated from Euphorbia poisonii.
PURITY: ≥99% (HPLC)
APPEARANCE: White amorphous solid.
SOLUBILITY: Soluble in 100% ethanol or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Ultrapotent capsaicin analog which stimulates protein kinase C (PKC). Potent agonist of TRPV1. Potent neurotoxin.
Product Specific Literature References
Structure-activity relations of polyfunctional diterpenes of the daphnane type. I. Revised structure for resiniferatoxin and structure-activity relations of resiniferonol and some of its esters: W. Adolf, et al.; J. Nat. Prod. 45, 347 (1982) Abstract
On the active principles of the spurge family (Euphorbiaceae). V. Extremely skin-irritant and moderately tumor-promoting diterpene esters from Euphorbia resinifera Berg: M. Hergenhahn, et al.; J. Cancer Res. Clin. Oncol. 108, 98 (1984) Abstract
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper: A. Szallasi & P.M. Blumberg; Neuroscience 30, 515 (1989) Abstract
Sensory neuron-specific actions of capsaicin: mechanisms and applications: S. Bevan & J. Szolcsányi; TIPS 11, 330 (1990) Abstract
Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes: A. Szallasi & P.M. Blumberg; Brain Res. 524, 106 (1990) Abstract
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor: A. Szallasi & P.M. Blumberg; Life Sci. 47, 1399 (1990) Abstract
Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons: J. Szolcsanyi, et al.; J. Pharmacol. Exp. Ther. 255, 923 (1990) Abstract
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin: S. Bevan, et al.; Br. J. Pharmacol. 107, 544 (1992) Abstract
Release of calcitonin gene-related peptide from sensory neurons: J.M. Lundberg, et al.; Ann. NY Acad. Sci. 657, 187 (1992) Abstract
Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine: G. Appendino & A. Szallasi; Life Sci. 60, 681 (1997), (Minireview) Abstract
Conformational studies on resiniferatoxin (RTX), an ultrapotent vanilloid agonist: S.F. Victory, et al.; Bioorg. Med. Chem. 6, 223 (1998) Abstract
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain: M.Z. Chou, et al.; Biochemistry 43, 2501 (2004) Abstract
Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells: M.R. Frey, et al.; Biochem. Pharmacol. 67, 1873 (2004) Abstract
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin: M. Raisinghani, et al.; J. Physiol. 567, 771 (2005) Abstract
Memory of pain: the effect of perineural resiniferatoxin: I. Kissin, et al.; Anesth. Analg. 103, 721 (2006) Abstract
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