ALEXIS Biochemicals: Resveratrol

ALX-270-125

Revised 25-Apr-08

Resveratrol
SYNONYMS	trans-3,4’,5-Trihydroxystilbene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-125-M050		50 mg	36.00 USD
ALX-270-125-M100		100 mg	50.00 USD
ALX-270-125-M250		250 mg	95.00 USD

Product Specification

FORMULA:	C₁₄H₁₂O₃
MW:	228.2
CAS NUMBER:	501-36-0
MERCK INDEX:	14: 8158
SOURCE/HOST:	Isolated from Polygonum cuspidatum.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	~65mg/ml soluble in DMSO, 100% ethanol or dimethyl formamide; slightly soluble in PBS, pH 7.2 (~100 µg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT.

Product Description

Shows cancer chemopreventive activity. Specific inhibitor of cyclooxygenase-1 (COX-1). Inhibits the hydroperoxidase activity of COX-1. Antioxidant. Potent activator of human deacetylase SIRT1. Protects against 4-hydroxynonenal (4-HNE) induced oxidative stress and apoptosis.

Product Specific Literature References

Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta: C.K. Chen, et al.; Gen. Pharmacol. 27, 363 (1996) Abstract
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997) Abstract
Cancer chemopreventive activity of resveratrol: M. Jang & J.M. Pezzuto; Drugs Exp. Clin. Res. 25, 65 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts: O. Kutuk, et al.; Biofactors 20, 1 (2004) Abstract
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats: A.R. Martin, et al.; Biochem. Pharmacol. 67, 1399 (2004) Abstract
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells: E. Sexton, et al.; Mol. Cancer 5, 45 (2006) Abstract
Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008) Abstract