ALEXIS Biochemicals: Reticulol

ALX-380-118

Revised 13-Mar-07

Reticulol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Topoisomerase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-118-C250		250 µg	140.00 USD
ALX-380-118-M001		1 mg	420.00 USD

Product Specification

FORMULA:	C₁₁H₁₀O₅
MW:	222.2
CAS NUMBER:	26246-41-3
SOURCE/HOST:	Isolated from Streptomyces sp.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide or acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Antibiotic. Inhibitor of cyclic adenosine 3’,5’-monophosphate phosphodiesterase and topoisomerase I (Topo I). Antitumor agent.

Product Specific Literature References

Reticulol, a new metabolic isocoumarin: L.A. Mitscher, et al.; Experientia 20, 258 (1964) Abstract
Isocoumarins from streptomyces mobaraensis: M.A.W. Eaton and D.W. Hutchinson; Tetrahedron Lett. 12, 1337 (1971)
Reticulol, an inhibitor of cyclic adenosine 3’, 5’-monophosphate phosphodiesterase: Y. Furutani, et al.; J. Antibiot. 28, 558 (1975) Abstract
Reticulol, an inhibitor of cyclic nucleotide phosphodiesterases: Y. Furutani, et al.; Agric. Biol. Chem. 41, 989 (1977)
Biosynthetic studies of reticulol, an isocoumarin, by 13C-NMR spectroscopy: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1581 (1977)
Inhibition of cyclic nucleotide phosphodiesterases by reticulol: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1587 (1977)
Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma: D.S. Lim, et al.; Chemotherapy 49, 146 (2003) Abstract
Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma: D.S. Lim, et al.; Chemotherapy 49, 257 (2003) Abstract
An Efficient Synthesis of 8-Hydroxy-6,7-dimethoxy-3-methylisocoumarin (6-O-methylreticulol) : A. Saeed and S. Ehsan; Chem. Heterocyc. Comp. 41, 1381 (2005)

Further Categories Containing This Product:

Antibiotics - Other Signal Transduction Pathway Modulators • Phosphodiesterases/Related Products • Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics

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